AME Results

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Labeling this number of sequences as 'positive' was found by AME to be optimal (or your primary sequence file contains this number of sequences and you also provided a control sequence file). The sequences were chosen as described above under "Labeling positives".

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Labeling this number of sequences as 'negative' was found by AME to be optimal (or you provided a control sequence file containing this number of sequences). The sequences are those remaining after the 'positive' sequences were chosen as described above under "Labeling positives".

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The number (percentage) of sequences labeled as 'positive' (Pos) and classified as 'positive' (TP), %TP = 100 * TP/Pos.
Labeling of sequences as 'positive' is described in the help bubble for "Pos". Classification is described above under "Classifying positives".

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The number (percentage) of sequences labeled as 'negative' (Neg) but classified as 'positive' (FP),
%FP = 100 * FP/Neg.
Labeling of sequences as 'negative' is described in the help bubble for "Neg". Classification is described above under "Classifying positives".

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The (optimal) score threshold for labeling sequences as 'positive' determined by AME. (See the note about "Labeling positives" in the section above.)

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The (optimal) score threshold for classifying sequences as 'positive' determined by AME (or provided by you using `--hit-odds-fraction` or `--fasta-threshold`).
By default, the true positive and false positive sequences are those with sequence motif scores ≥ the value shown.
If you specified `--poslist pwm`, then the true positive and false positive sequences are those with FASTA scores ≤ the value shown.

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The value of Pearson's correlation coefficient (ρ). It varies between -1 and +1. High values of ρ indicate strong correlation between the sequence motif scores and the sequence FASTA scores. Note that positive ρ means that sequence motif scores go up when sequence FASTA scores go down. The p-value of this method is the probability that ρ is at least as large as the observed value assuming there is no relation between the scores.

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The value of Spearman's rank correlation coefficient (ρ). It varies between -1 and +1. High values of ρ indicate strong correlation between the sequence motif score ranks and the sequence FASTA score ranks. Note that positive ρ means that sequence motif scores go up when sequence FASTA scores go down. The p-value of this method is the probability that ρ is at least as large as the observed value assuming there is no relation between the scores.

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The value of the mean squared error of the linear regression of X vs Y.

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The slope of the regression line: Y = mX + b.

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The Y-intercept of the regression line: Y = mX + b.

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# AME

## Analysis of Motif Enrichment

For further information on how to interpret these results please access https://meme-suite.org/meme/doc/ame-output-format.html.
To get a copy of the MEME software please access https://meme-suite.org.

If you use AME in your research, please cite the following paper:
Robert McLeay and Timothy L. Bailey, "Motif Enrichment Analysis: A unified framework and method evaluation", BMC Bioinformatics, 11:165, 2010, doi:10.1186/1471-2105-11-165. [full text]

Enriched Motifs | Input Files | Program information | Results in TSV Format

## Enriched Motifs

Logo | Database | ID | Alt ID | p-value | E-value | Pos Thresh | Pos | Neg | TP Thresh | TP (%) | FP (%) | Pearsons's CC (ρ) | Spearman's Rank CC (ρ) | Mean squared error | m | b
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---

## Input Files

#### Alphabet

#### Sequences

#### Motifs

Database | Source | Motif Count
--- | --- | ---

##### AME version

(Release date:
)
Copyright © Robert McLeay & Timothy Bailey meme-suite@uw.edu, 2009.

##### Command line summary