#ifndef OBJMGR_UTIL___AUTODEF__HPP
#define OBJMGR_UTIL___AUTODEF__HPP

/*  $Id: autodef.hpp 578777 2019-01-25 13:17:09Z bollin $
* ===========================================================================
*
*                            PUBLIC DOMAIN NOTICE
*               National Center for Biotechnology Information
*
*  This software/database is a "United States Government Work" under the
*  terms of the United States Copyright Act.  It was written as part of
*  the author's official duties as a United States Government employee and
*  thus cannot be copyrighted.  This software/database is freely available
*  to the public for use. The National Library of Medicine and the U.S.
*  Government have not placed any restriction on its use or reproduction.
*
*  Although all reasonable efforts have been taken to ensure the accuracy
*  and reliability of the software and data, the NLM and the U.S.
*  Government do not and cannot warrant the performance or results that
*  may be obtained by using this software or data. The NLM and the U.S.
*  Government disclaim all warranties, express or implied, including
*  warranties of performance, merchantability or fitness for any particular
*  purpose.
*
*  Please cite the author in any work or product based on this material.
*
* ===========================================================================
*
* Author:  Colleen Bollin
*
* File Description:
*   Creates unique definition lines for sequences in a set using organism
*   descriptions and feature clauses.
*/

#include <corelib/ncbistd.hpp>
#include <objects/seqfeat/BioSource.hpp>
#include <objects/seqfeat/Org_ref.hpp>
#include <objects/seqfeat/OrgMod.hpp>
#include <objects/seqfeat/SubSource.hpp>
#include <objects/seqfeat/OrgName.hpp>
#include <objects/seqfeat/Seq_feat.hpp>
#include <objects/seq/MolInfo.hpp>

#include <objmgr/bioseq_handle.hpp>
#include <objmgr/seq_entry_handle.hpp>
#include <objmgr/feat_ci.hpp>

#include <objmgr/util/autodef_available_modifier.hpp>
#include <objmgr/util/autodef_source_desc.hpp>
#include <objmgr/util/autodef_source_group.hpp>
#include <objmgr/util/autodef_mod_combo.hpp>
#include <objmgr/util/autodef_feature_clause.hpp>
#include <objmgr/util/autodef_options.hpp>

BEGIN_NCBI_SCOPE
BEGIN_SCOPE(objects)    

class NCBI_XOBJEDIT_EXPORT CAutoDef
{
public:
    
    typedef set<CAutoDefAvailableModifier> TAvailableModifierSet;

    CAutoDef();
    ~CAutoDef();
 
    void AddSources(CSeq_entry_Handle se);
    void AddSources(CBioseq_Handle bh);
    CRef<CAutoDefModifierCombo> FindBestModifierCombo();
    CAutoDefModifierCombo* GetAllModifierCombo();
    CAutoDefModifierCombo* GetEmptyCombo();
    unsigned int GetNumAvailableModifiers();
    string GetOneSourceDescription(const CBioseq_Handle& bh);
    string GetOneFeatureClauseList(CBioseq_Handle bh, unsigned int genome_val);
    string GetOneDefLine(CAutoDefModifierCombo* mod_combo, const CBioseq_Handle& bh);
    string GetOneDefLine(const CBioseq_Handle& bh);
    
    void SetOptionsObject(const CUser_object& user);
    CRef<CUser_object> GetOptionsObject() const { return m_Options.MakeUserObject(); }

    void SetFeatureListType(CAutoDefOptions::EFeatureListType feature_list_type);
    void SetMiscFeatRule(CAutoDefOptions::EMiscFeatRule misc_feat_rule);
    void SetProductFlag(CBioSource::EGenome product_flag);
    void SetNuclearCopyFlag(CBioSource::EGenome product_flag);
	void SetSpecifyNuclearProduct (bool specify_nuclear_product);
    void SetAltSpliceFlag (bool alt_splice_flag);
    void SetSuppressLocusTags(bool suppress_locus_tags);
    void SetSuppressAllele(bool suppress_allele);
    void SetGeneClusterOppStrand(bool gene_opp_strand);
    void SetSuppressFeatureAltSplice (bool suppress_alt_splice);
    void SuppressMobileElementAndInsertionSequenceSubfeatures(bool suppress);
    void SuppressMiscFeatSubfeatures(bool suppress);
    void SetKeepExons(bool keep);
    void SetKeepIntrons(bool keep);
    void SetKeepRegulatoryFeatures(bool keep);
    void SetKeepLTRs(bool keep);
    void SetKeep3UTRs(bool keep);
    void SetKeep5UTRs(bool keep);
    void SetKeepuORFs(bool keep);
    void SetKeepOptionalMobileElements(bool keep);
    void SetKeepPrecursorRNA(bool keep);
    void SetKeepRepeatRegion(bool keep);
    void SetKeepMiscRecomb(bool keep);
	void SetUseNcRNAComment (bool use_comment);
    void SetUseFakePromoters (bool use_fake);
    void SetCustomFeatureClause(const string& custom_feature_clause);
    
    void SuppressFeature(const objects::CFeatListItem& feat); 
    void SuppressFeature(objects::CSeqFeatData::ESubtype subtype);
    
    typedef vector<CRef<CAutoDefModifierCombo>> TModifierComboVector;
    
    void GetAvailableModifiers(TAvailableModifierSet &mod_set);
    
    void Cancel() { m_Cancelled = true; }
    bool Cancelled() { return m_Cancelled; }

    static string GetKeywordPrefix(CBioseq_Handle bh);

    static bool RegenerateSequenceDefLines(CSeq_entry_Handle se);
    static string RegenerateDefLine(CBioseq_Handle bh);
    
    static CRef<CUser_object> CreateIDOptions(CSeq_entry_Handle seh);

private:
    typedef vector<unsigned int> TModifierIndexVector;
    typedef vector<CSeq_entry_Handle> TSeqEntryHandleVector;

    CAutoDefModifierCombo m_OrigModCombo;

    CAutoDefOptions m_Options;

    // feature clause specifications
    bool         m_Cancelled;
    
    void x_SortModifierListByRank
        (TModifierIndexVector& index_list,
         CAutoDefSourceDescription::TAvailableModifierVector& modifier_list);
    void x_GetModifierIndexList
        (TModifierIndexVector& index_list,
         CAutoDefSourceDescription::TAvailableModifierVector& modifier_list);
    
    string x_GetNonFeatureListEnding();

    string x_GetFeatureClauses(const CBioseq_Handle& bh);
    string x_GetFeatureClauseProductEnding(const string& feature_clauses,
                                           CBioseq_Handle bh);
                              
    void x_RemoveOptionalFeatures(CAutoDefFeatureClause_Base *main_clause, const CBioseq_Handle& bh);
                                  
    
    bool x_IsOrgModRequired(unsigned int mod_type);
    bool x_IsSubSrcRequired(unsigned int mod_type);
    
    bool x_IsFeatureSuppressed(CSeqFeatData::ESubtype subtype);
    
    void GetMasterLocation(CBioseq_Handle &bh, CRange<TSeqPos>& range);
    bool IsSegment(const CBioseq_Handle& bh);
    bool x_Is5SList(CFeat_CI feat_ci);
    bool x_IsSingleMiscFeat(CFeat_CI feat_ci);
    string x_GetHumanSTRFeatureClauses(CBioseq_Handle bh, const CUser_object& comment);
    bool x_IsHumanSTR(const CUser_object& obj);

    string x_GetOneNonFeatureClause(CBioseq_Handle bh, unsigned int genome_val);

};  //  end of CAutoDef


inline
void CAutoDef::SetFeatureListType(CAutoDefOptions::EFeatureListType feature_list_type)
{
    m_Options.SetFeatureListType(feature_list_type);
}


inline
void CAutoDef::SetMiscFeatRule(CAutoDefOptions::EMiscFeatRule misc_feat_rule)
{
    m_Options.SetMiscFeatRule(misc_feat_rule);
}


inline
void CAutoDef::SetProductFlag(CBioSource::EGenome product_flag)
{
    m_Options.SetProductFlag(product_flag);
}


inline
void CAutoDef::SetNuclearCopyFlag(CBioSource::EGenome product_flag)
{
    m_Options.SetNuclearCopyFlag(product_flag);
}


inline
void CAutoDef::SetSpecifyNuclearProduct (bool specify_nuclear_product)
{
    m_Options.SetSpecifyNuclearProduct(specify_nuclear_product);
}


inline
void CAutoDef::SetAltSpliceFlag (bool alt_splice_flag)
{
    m_Options.SetAltSpliceFlag(alt_splice_flag);
}


inline
void CAutoDef::SetSuppressLocusTags (bool suppress_locus_tags)
{
    m_Options.SetSuppressLocusTags(suppress_locus_tags);
}


inline
void CAutoDef::SetGeneClusterOppStrand (bool gene_opp_strand)
{
    m_Options.SetGeneClusterOppStrand(gene_opp_strand);
}


inline
void CAutoDef::SetSuppressFeatureAltSplice (bool suppress_alt_splice)
{
    m_Options.SetSuppressFeatureAltSplice(suppress_alt_splice);
}


inline
void CAutoDef::SuppressMobileElementAndInsertionSequenceSubfeatures(bool suppress)
{
    m_Options.SetSuppressMobileElementSubfeatures(suppress);
}


inline 
void CAutoDef::SuppressMiscFeatSubfeatures(bool suppress)
{
    m_Options.SetSuppressMiscFeatureSubfeatures(suppress);
}


inline
void CAutoDef::SetKeepExons(bool keep)
{
    m_Options.SetKeepExons(keep);
}


inline
void CAutoDef::SetKeepIntrons(bool keep)
{
    m_Options.SetKeepIntrons(keep);
}


inline
void CAutoDef::SetKeepRegulatoryFeatures(bool keep)
{
    m_Options.SetKeepRegulatoryFeatures(keep);
}

inline
void CAutoDef::SetKeepLTRs(bool keep)
{
    m_Options.SetKeepLTRs(keep);
}


inline
void CAutoDef::SetKeep3UTRs(bool keep)
{
    m_Options.SetKeep3UTRs(keep);
}


inline
void CAutoDef::SetKeep5UTRs(bool keep)
{
    m_Options.SetKeep5UTRs(keep);
}


inline
void CAutoDef::SetKeepuORFs(bool keep)
{
    m_Options.SetKeepuORFs(keep);
}


inline
void CAutoDef::SetKeepOptionalMobileElements(bool keep)
{
    m_Options.SetKeepMobileElements(keep);
}

inline
void CAutoDef::SetKeepPrecursorRNA(bool keep)
{
    m_Options.SetKeepPrecursorRNA(keep);
}

inline
void CAutoDef::SetKeepRepeatRegion(bool keep)
{
    m_Options.SetKeepRepeatRegion(keep);
}

inline
void CAutoDef::SetKeepMiscRecomb(bool keep)
{
    m_Options.SetKeepMiscRecomb(keep);
}

inline
void CAutoDef::SetUseNcRNAComment(bool use_comment)
{
    m_Options.SetUseNcRNAComment(use_comment);
}


inline
void CAutoDef::SetUseFakePromoters(bool use_fake)
{
    m_Options.SetUseFakePromoters(use_fake);
}


inline
void CAutoDef::SetCustomFeatureClause(const string& custom_feature_clause)
{
    m_Options.SetCustomFeatureClause(custom_feature_clause);
}

END_SCOPE(objects)
END_NCBI_SCOPE

#endif //OBJMGR_UTIL___AUTODEF__HPP
