You'll need to add the following lines to /etc/rc.d/rc.local: # Start vboxdrv if [ -x /etc/rc.d/rc.vboxdrv ]; then /etc/rc.d/rc.vboxdrv start fi This will load the support kernel module for VirtualBox. You'll then need to add the following lines to /etc/rc.d/rc.local_shutdown: # Stop vboxdrv if [ -x /etc/rc.d/rc.vboxdrv ]; then /etc/rc.d/rc.vboxdrv stop fi Any user accounts that plan to use virtualbox will need to be members of the "vboxusers" group. In order to use USB devices in VirtualBox Guests you may have to restart your host system after installing the virtualbox package.