# Manual Probe Correlation Filter

The manual probe correlation filter operates in a similar way to the probe list correlation filter, in that it allows you to find probes which show correlation to a set of reference quantitation profiles across several Data Stores. The difference in the manual filter is that the reference profiles are generated interactively so you can construct whichever quantitation profiles you like.

To create a correlation profile simply select the data stores you want to use from the list on the left and then drag the green boxes on the profile plot to generate the profile you wish to correlate against. You can filter against up to 12 profiles simultaneously. If a probe is able to correlate against more than one of the constructed profiles then it will be added to the profile with the highest correlation (or lowest if your correlation cutoff is less than 0). In this way you can ensure that you get no overlap between correlation clusters.

## Options

- You can choose which data stores you want to use for your correlation. You must choose at least 3 stores and there is no upper limit to the number you choose.
- You can choose how many manual profiles you want to create
- You must generate your reference profiles using the selected data stores.
- You can choose how correlated a probe has to be to the reference profile in order to be included in the filtered output. If you specify a negative R value then the filter will search for correlation less than that value, so this becomes an anti-correlation filter